Anterior cruciate ligament injury
Conditions
Interventions
Observers (Postoperative use of fondaparinux sodium in patients):None
control group (Patients who use enoxaparin sodium after surgery):None
Sponsors
Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Patients with high VTE risk and undergoing initial reconstruction surgery for ACL injury in Caprini score, aged 18-45 years old; 2. The patient's platelet count and coagulation function are normal; 3. Received anticoagulant therapy with fondaparinux sodium or enoxaparin sodium after surgery; 4. The subjects and their families have been informed of the nature of the study, understand the regulations of the study, have good compliance, and have signed an informed consent form;
Exclusion criteria
Exclusion criteria: 1. Poor control of hypertension, with systolic blood pressure>180 mmHg or diastolic blood pressure>110 mmHg; 2. Patients with mental illness or poor compliance; 3. Patients with adverse drug reactions; 4. Those who require long-term use of anticoagulant and antiplatelet drugs due to their illness; 5. Individuals with a history of deep vein thrombosis or pulmonary embolism in the lower limbs; 6. Previously diagnosed with heparin induced thrombocytopenia; 7. Patients with a history of long-term smoking, alcoholism, and drug abuse; 8. Patients with degenerative or autoimmune arthritis of the knee joint itself (knee osteoarthritis, rheumatoid arthritis, etc.);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| D- Dimer;INR;APTT;PT;FDP;Lower limb vascular ultrasound; | — |
Secondary
| Measure | Time frame |
|---|---|
| thrombelastogram;SR;CRP;IL--6;Circumferential diameter of knee joint; | — |
Countries
China
Contacts
Public ContactLihan Shi
Hospital of Chengdu University of Traditional Chinese Medicine
Outcome results
None listed