Elderly patients with colorectal cancer
Conditions
Interventions
Open surgery+ QLB-group :receive bilateral QLB with 1.3mg/kg ropivacaine 0.375% on both side
Open surgery+ EA-group:epidural analgesia with 0.15mg/kg/h ropivacaine 0.25%
Laparoscopic surgery+ QLB-group :receive bilateral QLB with 1.3mg/kg ropivacaine 0.375% on both side
Laparoscopic surgery+ EA-group:epidural analgesia with 0.15mg/kg/h 0.25%
Control group 1 (Open surgery):None
Control group 2 (Laparoscopic surgery):None
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Aged 65 to 80 years old; 2) ASA level I or II; 3) Patients undergoing colorectal resection surgery; 4) 18 = Body Mass Index (BMI) = 29 kg/m2; 5) Voluntarily participate and sign an informed consent form; 6) The patient had no record of taking opioid analgesics 2 weeks prior to surgery; 7) Having a certain level of cultural background and a good understanding of the Digital Pain Scale (NRS).
Exclusion criteria
Exclusion criteria: 1) Individuals who are known to be allergic to the main drug or any of the excipients in this study protocol; 2) Patients who do not agree to receive lumbar quadratus block or epidural block; 3) Patients with lumbar disc herniation accompanied by lower limb radiating pain; 4) Patients with a history of chronic pain, current cancer pain, and long-term use of opioid drugs; 5) Patients with severe hematological disorders (anemia, thrombocytopenia, etc.) and peripheral vascular diseases, with coagulation abnormalities (platelet count less than 100 * 10 ^ 9/L, international standardized ratio (INR) greater than 1.4); 6) Individuals who have taken anticoagulant drugs, hormones, and coagulation disorders before surgery; 7) Preoperative liver and kidney function: alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen (BUN), creatinine (Cr) abnormalities (ALT and AST are 1.5 times higher than the upper limit of normal, BUN and Cr are higher than the upper limit of normal); 8) Coronary heart disease, uncontrolled or difficult to control hypertension: systolic blood pressure (SBP) = 160mmHg or diastolic blood pressure (DBP) = 100mmHg; 9) Respiratory dysfunction, respiratory failure; 10) Patients with mental illness (untreated or poorly controlled schizophrenia, severe depression or bipolar disorder) 11) Individuals with communication (language) barriers that hinder accurate assessment of preoperative and postoperative pain and/or ability to answer pain related questions; 12) Individuals with poor compliance and inability to complete the experiment according to the research protocol; 13) Participated in other drug trials within 30 days prior to selection; 14) Individuals with a history of severe trauma or major surgery within the past month (excluding those undergoing open abdominal/thoracic surgery under general anesthesia and complete intravenous anesthesia); 15) The researchers believe that participants are not suitable for this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| numeric rating scale ; | — |
Secondary
| Measure | Time frame |
|---|---|
| block completion time;one-time success rate;opioid consumption;time to recovery of intestinal function;incidence of postoperative nausea and vomiting during the first 48 hours;the first time the patient walked on the ground; | — |
Countries
China
Contacts
Public ContactDairu Jia
The Second Hospital of Hebei Medical University
Outcome results
None listed