Neonatal acute respiratory distress syndrome
Conditions
Interventions
NARDS group:none
Control group:none
Sponsors
Children's Hospital Affiliated to Chongqing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) < 28-day term infants or preterm infants within 44 weeks of corrected gestational age; 2) Hospitalized in the Children's Hospital of Chongqing Medical University within 2 weeks after birth; 3) Children diagnosed with NARDS, NRDS or non-bacterial pneumonia during hospitalization were matched for gestational age, birth weight, postnatal age, delivery mode and feeding mode, and included in the NARDS group and non-NARDS group respectively. The diagnosis of NARDS refers to the "Montreux criteria" criteria: (1) Acute respiratory distress occurs after a clear or suspected clinical injury, oxygenation disorder accompanied by decreased residual volume, and positive pressure ventilation is required to facilitate lung reexpansion; (2) Neonatal respiratory distress syndrome, neonatal transient respiratory hypertrophiy, congenital lung malformations and PS synthesis related gene defects were excluded from the pathophysiological basis of NARDS; (3) Pulmonary imaging showed bilateral diffuse irregular decreased light transmittance, exudation, or white lung, and these changes could not be fully explained by other causes, such as local effusion, atelectasis, neonatal respiratory distress syndrome, neonatal transient rapid respiration, or congenital lung malformations; (4) Respiratory failure due to pulmonary edema cannot be completely explained by heart failure; (5) Severity of the disease: mild was 4 = oxygen index (OI) <8, moderate was 8 = OI<16, severe was OI = 16. If the above 5 sample criteria are met at the same time, NARDS can be diagnosed, and the severity of the disease can be assessed according to Article 5.
Exclusion criteria
Exclusion criteria: 1) There are congenital malformations affecting respiratory function, such as congenital heart disease, diaphragmatic hernia, pulmonary artery stenosis, respiratory structure abnormalities, genetic metabolic diseases, etc. 2) Can not be paired into the group; 3) Incomplete sample collection and lack of clinical data; 4) Parents requested withdrawal from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| microbial flora;Microbial tryptophan metabolites; | — |
Countries
China
Contacts
Public ContactJingli Yang
Children's Hospital Affiliated to Chongqing Medical University
Outcome results
None listed