allergic rhinitis
Conditions
Interventions
treatment group:Nasal application of exosomes
control group:Nasal spray application placebo
Sponsors
Changzhou Third People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria established in the Guidelines for the Diagnosis and Treatment of Allergic Rhinitis (2015, Tianjin); 2. Age: 18-65 years old; 3. Standardized anti allergic drug treatment (including continuous local glucocorticoids, local and oral antihistamines, nasal irrigation, etc.) is ineffective or ineffective; 4. Voluntarily sign an informed consent form, understand and accept the duration of the study, be able and willing to comply with all requirements, including planned treatment, follow-up, and other research procedures.
Exclusion criteria
Exclusion criteria: 1. Suffering from other diseases of the nasal cavity and sinuses (such as nasal polyps, chronic rhinitis, chronic sinusitis, frame structure deformities, etc.); 2. Pregnancy, diagnosis of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, etc; 3. Patients with serious systemic diseases, such as tumor, digestive tract ulcer, diabetes, tuberculosis, mental disease, etc; 4. Specific infections such as syphilis, leprosy, and tuberculosis; 5. Subjects who have been using immunosuppressants for a long time; 6. The researchers believe that participants who are not suitable to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum inflammatory factors;Nasal lavage fluid inflammatory factors;Flow cytometric analysis of lymphocyte clusters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum specific IgE;endoscopy;olfactometry; | — |
Countries
China
Contacts
Public ContactXue Jianrong
Changzhou Third People's Hospital
Outcome results
None listed