Unstable angina
Conditions
Interventions
Experimental group:Remote ischemic conditioning (RIC)
Control group:Sham Remote ischemic conditioning (Sham RIC)
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with unstable angina (primary angina, worsening angina, resting angina, post-infarction angina, variant angina) who are scheduled for coronary angiography 2. Be older than 18 years and younger than or equal to 75 years of age 3. Have normal cognitive function, MMSE score >16, and be able to cooperate with rehabilitation therapy 4. Agree to participate in the trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. hs-cTnT elevation greater than 2 times the upper limit of normal (99th percentile of the upper reference limit) in combination with other evidence of myocardial ischemia 2. Stroke or myocardial infarction within 30 days 3. Thrombolytic therapy within 30 days 4. Uncontrolled hypertension: systolic blood pressure > 160 mmHg or diastolic blood pressure > 100 mmHg 5. Contraindication to physiologic ischemia training, vascular or soft tissue injury, etc. 6. The presence of peripheral neuropathy, peripheral arterial disease, superficial thrombophlebitis, acute venous thrombosis 7. Other reasons that the investigator considers inappropriate for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Periprocedural myocardial injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Periprocedural myocardial infarction;Major adverse cardiac events (MACE);All-cause mortality;Myocardial infarction;Rehospitalization for heart failure;Unplanned revascularization;Gensini Score;Arrhythmia;Seattle Angina Questionnaire (SAQ);Two-dimensional echocardiography; | — |
Countries
P.R. China
Contacts
Public ContactXiao Lu
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed