osteoarthritis of the knee
Conditions
Interventions
Duloxetine group:Oral duloxetine 60 mg/dose once daily beginning two days before surgery and continuing through 14 days postoperatively
Pregabalin group:Oral pregabalin 150 mg/dose twice daily beginning two days before surgery and continuing through 14 days postoperatively
drug combination group:Oral duloxetine 60 mg/dose once a day and oral pregabalin 150 mg/dose twice a day starting two days prior to surgery and continuing until 14 days postoperatively
control group:After the 6h postoperative fasting period, oral erixib tablets 0.1g, codeine 500mg, starting on the second postoperative day and up to 14 days postoperatively, oral erixib tablets 0.1g/d
Sponsors
Honghui Hospital, Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1 Eligible for surgical indications, with diagnostic findings of osteoarthritis of the knee through clinical and imaging tests; 2 Subjects in the study were adult patients, aged 50-80 years, scheduled to undergo primary TKA; 3 American Society of Anesthesiologists (ASA) assessment classification of 1-3; 4 No contraindications to medication; 5 Patients agreed to sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1 Patients with a history of hepatic or renal unhealthiness, severe cardiopulmonary disease, severe gastrointestinal disease, or psychiatric disease; 2 Patients who are allergic or intolerant to duloxetine, pregabalin or anesthetic drugs; 3 Patients taking duloxetine, pregabalin, or opioids within 2 weeks before surgery; 4 Patients with mental illness and cognitive impairment; 5 Patients with previous open surgery on the same side of the knee.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analog scores;keen society score; | — |
Secondary
| Measure | Time frame |
|---|---|
| SF-36;Knee range of motion;Opioid consumption;length of stay; | — |
Countries
China
Contacts
Public ContactWu Haodong; Huang Yuanchi
Honghui Hospital, Xi'an Jiaotong University
Outcome results
None listed