Herpes virus infection after haploid transplantation
Conditions
Interventions
Gold Standard:The gold standard for diagnosis is the quantitative detection of blood EBV-DNA and CMV-DNA by PCR
Index test:dPCR
Sponsors
Shanghai Children's Medical Center
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1: Age 0-18 years old, gender unlimited, and signed informed consent 2: Haploid hematopoietic stem cell transplantation with allogeneic hematopoietic stem cell transplantation Pointers and non-extracorporeal T cell removal planned 3: It is possible to complete EBV-DNA and CMV-DNA blood tests within 1 week before transplantation, 30 days after transplantation, and 60 days after transplantation
Exclusion criteria
Exclusion criteria: 1: Patients diagnosed with chronic active Epstein-Barr virus infection or Epstein-Barr virus-associated lymphoproliferative tissue disease before transplantation 2: In vitro T cell removal of haploid hematopoietic stem cell transplantation patients 3: Patients with severe anemia or severe clotting disorder who are not suitable for peripheral blood extraction during follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EBV;CMV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity;Positive predicative value;negative predictive value, NPV; | — |
Countries
China
Contacts
Public ContactXi Mo
Shanghai Children's Medical Center
Outcome results
None listed