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To explore the effect and mechanism of paired association stimulation on wakefulness in patients with chronic consciousness disorder based on neuroelectrophysiology

To explore the effect and mechanism of paired association stimulation on wakefulness in patients with chronic consciousness disorder based on neuroelectrophysiology

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400079832
Enrollment
Unknown
Registered
2024-01-13
Start date
2023-02-03
Completion date
Unknown
Last updated
2024-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

disturbance of consciousness

Interventions

control group:Routine rehabilitation training
MNS group:MNS
PAS group:pas

Sponsors

Zhejiang Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ? Age > 18 years old, duration > 28 days; ? A ccording to the CRS-R scale, it was diagnosed as VS or MCS in pDOC; ? No history of epilepsy or other neuropsychiatric diseases; ? No implant medical equipment such as skull repair materials, shunt devices, aneurysm clips, deep electrodes, etc.; ? Stable intracranial condition, no obvious cerebral edema, no severe cerebral atrophy; ? The patient's family members get the right to know, and voluntarily sign the informed consent.

Exclusion criteria

Exclusion criteria: ? A history of tumor; ? History of severe arrhythmia or pacemaker implantation; ? History of median nerve function injury; ? Patients with severe intracranial infection; ? Other situations that are not suitable for rTMS or MNS intervention.

Design outcomes

Primary

MeasureTime frame
coma recovery scalerevised,CRS-R;Glasgow coma scale,GCS;

Secondary

MeasureTime frame
electroencephalo-graph;

Countries

China

Contacts

Public ContactLiu Yong

Zhejiang Provincial People's Hospital

1163535520@qq.com+86 137 3810 0354

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026