Colon Cancer, Rectal cancer
Conditions
Interventions
Postoperative multimodal analgesia group (POA group):Intraoperative administration of 0.3 µg/kg/h dexmedetomidine should be continuously pumped until 30 minutes before the end of surgery, and flurbipr
Multimodal preanalgesia group (PRA group):Dexmedetomidine 0.5µg/kg was given 10min before anesthesia induction, and Intraoperative maintenance of 0.3 µ G/kg/h dexmedetomidine should be continuously pu
Sponsors
Department of Anesthesiology, the Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) age =65 years old; (2) ASA ?-?; (3) Selective laparoscopic colorectal surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: (1) Previous history of gastrointestinal motility disorders and abdominal surgery; (2) vital organ dysfunction, such as severe liver and kidney dysfunction, second or third degree atrioventricular block, or tachyarrhythmia (baseline heart rate 800 mL); (7) ASA ?-?, emergency surgery, and conversion to open surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative gastrointestinal dysfunction;The abundance of gut bacterial genera;Concentrations of short-chain fatty acids (SCFAs); | — |
Secondary
| Measure | Time frame |
|---|---|
| inflammatory factor;The time of the first exhaust;Time of first oral intake;The incidence and severity of postoperative nausea and vomiting;VAS;Postoperative delirium incidence rate;Length of hospital stay, hospital costs;Incidence of adverse events;The circulation fluctuated during the operation;Intraoperative drug dosage; | — |
Countries
China
Contacts
Public ContactLiu Chao-Lei
Department of anesthesiology, the Second Hospital of Hebei Medical University
Outcome results
None listed