Patients with normal ovarian response to assisted reproduction
Conditions
Interventions
hCG group:10000 IUHCG triggers ovulation
GnRH-a group:0.2 mg triptorelin triggers ovulation
Dual trigger group:0.2 mg triptorelin plus1500 IUHCG
Sponsors
Sichuan Academy of Medical Sciences& Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: women aged 20–35 years with a body mass index (BMI) of 18.5–28 kg/m², anti-Müllerian hormone (AMH) levels of 1.1–4.0 ng/mL, baseline follicle-stimulating hormone (FSH) levels of 3–15 IU/L, and baseline LH levels >3 IU/L. Eligible participants included those with female factor infertility (tubal factors, pelvic adhesions, or mild endometriosis), mild male factor infertility, or unexplained infertility. A normal response was defined as retrieving 4–15 oocytes, with a maximum E2 level <2500 pg/mL, an antral follicle count of 7–14, and those undergoing their first IVF/ICSI treatment.
Exclusion criteria
Exclusion criteria: secondary infertility; poor or high ovarian stimulation response; severe male factor infertility including oligospermia or azoospermia; endocrine disorders such as diabetes mellitus, hyperprolactinemia, thyroid dysfunction, congenital adrenal hyperplasia, Cushing syndrome, polycystic ovary syndrome; uterine abnormalities (endometrial polyps, submucosal fibroids, or myomas with a diameter of =5 cm, uterine cavity adhesions, and septate uterus); and patients who were not candidates for fresh embryo transfer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MII oocyte rate;The number of 2PN embryos;Number of transferable D3 embryos;Number of good-quality D3 embryo;Number of blastocysts formed;Number of good-quality blastocysts;Clinical pregnancy rate;hCG-positive rate;Biochemical pregnancy rate;Early miscarriage rate;Live birth rate;Number of oocytes;Number of follicles >14 mm; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of embryos transferred;Endometrial thickness on transfer day;Total gonadotropin dose;Days on gonadotropin;Total antagonist dose;Days on antagonist;Basal hormone level; | — |
Countries
China
Contacts
Public ContactLi Linfeng
Sichuan Academy of Medical Sciences& Sichuan Provincial People's Hospital
Outcome results
None listed