Invasive fungal infection
Conditions
Interventions
Treatment group:Fluconazole 200mg
One group of patients with IgG > 7mg/ml or absolute NK cell count > 6.5?10^4/L:non-prophylactic
Sponsors
Huadong Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: After autologous hematopoietic stem cell transplantation or allogeneic hematopoietic stem cell transplantation or ? after receiving strong cytotoxic drugs (such as high dose of CTX) or ? after a long course of high dose of glucocorticoids (0.5mg/kg predtisone for more than 1 month) or ? after using immunosuppressive drugs such as rituximab, it is necessary to meet that granulocytosis has recovered or no granulocytosis. Patients who do not require fungal prophylaxis according to current guidelines (i.e., patients who have developed grade III to IV graft-versus-host disease during allogeneic hematopoietic stem cell transplantation).
Exclusion criteria
Exclusion criteria: 1)patients with acute myeloid leukemia or other hematological malignancies had granuloidosis for more than one week after chemotherapy. 2)Patients with allogeneic hematopoietic stem cell transplantation who have developed grade III to IV acute graft-versus-host disease need fungal prophylaxis according to guidelines. 3) Participants who have participated in other clinical trials within 30 days. 4) Pregnant and nursing patients. 5) The patient has another type of tumor except superficial bladder cancer, basal cell or squamous cell carcinoma of the skin, cervical intraepithelial carcinoma (CIN), or prostate intraepithelial carcinoma (PIN) 6) Have an active viral or bacterial infection that is not controlled with appropriate anti-infective treatment 7) serologic positive for known HIV or active hepatitis C virus; Patients with active hepatitis B virus, manifested as elevated HBV titer and abnormal liver function, need strict anti-hepatitis B virus treatment, and can be considered for inclusion after hepatitis B virus control (HBV titer decline). Hepatitis B major Sanyang, small sanyang patients, such as HBV-DNA< 500, can be enrolled after regular antiviral treatment. 8) A person with a mental disorder or other condition who is unable to cooperate with the requirements of research treatment and monitoring
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immunoglobulin level;Incidence of invasive fungal infections; | — |
Countries
China
Contacts
Public ContactJiexian Ma
Huadong Hospital
Outcome results
None listed