Effects of cerebral hemodynamic changes on delirium and neurocognitive function in septic shock patients

Influences of cerebral hemodynamic changes on delirium and neurocognitive function in septic shock patients - Effects of cerebral hemodynamic changes on delirium and neurocognitive function in septic shock patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400079809

Enrollment

Unknown

Registered

2024-01-12

Start date

2024-01-15

Completion date

Unknown

Last updated

2024-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic shock Delirium Cognitive function

Interventions

Delirium group:There was no intervention. This is an observational study

Non-delirium group:There was no intervention. This is an observational study

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: In February 2016, at the 45th Annual Meeting of Critical Care Medicine, the American Society of Critical Care Medicine (SCCM) and the European Society of Critical Care Medicine (ESICM) jointly issued the definition and diagnostic criteria for Sepsis 3.0, namely, sepsis is defined as a life-threatening organ dysfunction caused by the host's maladjusted response to infection. Septic shock is the onset of persistent hypotension on the basis of sepsis and the need for vasoactive agents (norepinephrine) to maintain mean arterial pressure (MAP) =65mmHg and blood lactic acid concentration > 2mmol/L after full volume resuscitation. The diagnosis was finally confirmed by three experienced clinicians.

Exclusion criteria

Exclusion criteria: (1) Under the age of 18. (2) History of mental disorders or craniotomy. (3) neurological diseases (definite intracranial lesions, such as cerebral hemorrhage, subarachnoid hemorrhage, craniocerebral trauma, stroke, intracranial infection, etc.). (4) Hepatic failure combined with hepatic encephalopathy is suspicious. (5) Taking antidepressant or antiepileptic medications. (6) Drug or poison poisoning, alcohol dependence. (7) Pregnancy. (8) Severely impaired hearing and vision. (9) Cervical vascular examination, head MRI/CT and TCD examination found abnormalities (such as carotid artery plaque, thrombosis, etc.). (10) TCD/TCCD could not detect the blood flow signal in the temporal window. Sources of literature support (based on previous prospective observational studies)

Design outcomes

Primary

Measure	Time frame
Transient hyperemia response rate;	—

Secondary

Measure	Time frame
APACHE ?score;SOFA score;Sedative and analgesic medications;Continuous renal replacement therapy;	—

Countries

China

Contacts

Public ContactQing Feng

Peking University Shenzhen Hospital

764976758@qq.com+86 135 3805 7735

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026