Essential hypertension with microalbuminuria
Conditions
Interventions
Imidapril hydrochloride group:Oral imidapril hydrochloride
Bisoprolol fumarate group:Oral Bisoprolol fumarate
Imidapril hydrochloride+Bisoprolol fumarate group:Oral imidapril hydrochloride+Bisoprolol fumarate
Sponsors
Ruijin Hospital Ethics Committee Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) The subjects voluntarily agree to participate in the study and sign a written informed consent; (2) Age 18-75 years old, male or female; (3) After clinical diagnosis, diagnosed as essential hypertension patients, in line with the diagnostic criteria for essential hypertension [systolic blood pressure = 140mmHg, and/or diastolic blood pressure =90 mmHg]; (4) Urinary ACR 30-300mg/g or 24-hour urinary protein quantification: 30-300mg/24h; (5) Not taking antihypertensive drugs in the past 2 weeks or stopping the original antihypertensive drugs for more than 2 weeks; (6) 24-hour ambulatory blood pressure was greater than 130/80mmHg.
Exclusion criteria
Exclusion criteria: (1) Those who have a history of allergy or contraindications to the investigational drugs and excipients; (2) A history of severe liver and kidney disease; (3) Patients with severe cardiovascular and cerebrovascular diseases within 6 months before enrollment; (4) Patients with respiratory cough (bronchitis, COPD, asthma, etc.) and throat discomfort; (5) Pregnant and lactating women; (6) Patients with atrial fibrillation, severe arrhythmia, bradycardia (<60 beats /min) and atrioventricular block (7) Suspected or confirmed secondary hypertension; (8) ambulatory blood pressure monitoring is not qualified; (9) Other drugs that affect blood pressure, such as alpha-blockers, must be used; (10) The researcher thinks that it is not suitable to participate in this researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure;Urinary protein;Heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dry cough adverse reaction; | — |
Countries
China
Contacts
Public ContactWang Jiguang
Ruijin Hospital Ethics Committee Shanghai JiaoTong University School of Medicine
Outcome results
None listed