ischemic stroke
Conditions
Interventions
control group:Placebo
VK2 group :vitamin k2
Zinc group:Zinc
Sponsors
Harbin Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) 40-70 years old; 2) Patients with new onset ischemic stroke within 7 days without previous significant limb paralysis, NIHSS score 5-15 and muscle strength level 2-4; 3) Sign the informed consent form voluntarily.
Exclusion criteria
Exclusion criteria: 1) presence of disturbance of consciousness, aphasia, or dysphagia; 2) diagnosed or suspected with cerebral hemorrhage, cardiogenic cerebral infarction, atrial fibrillation; 3) receiving thrombolytic therapy; 4) severe congestive heart failure, malignant hypertension, chronic gastrointestinal malabsorption (e.g., celiac disease, short bowel syndrome); significant hepatic and renal impairment; Persistent malignancy (continuous treatment, or diagnosis of malignancy less than 5 years); 5) suffered musculoskeletal disease or cognitive impairment prior to stroke; 6) a history of major surgery within the past year; Patients with previous total or subtotal thyroidectomy or current treatment with thyroid hormone or parathyroid hormone; 7) subjects have taken zinc, vitamin K2, or a vitamin K antagonist (e.g., warfarin) within 1 month before trial; 8) Currently on a fixed dose or with plans to use cognitive or neuro-improving drugs during the study, such as cholinesterase inhibitors, methoxamine, purines, vitamins (e.g., vitamin E, vitamin B series), and cephalomyelin; 9) patients with normal eating restriction or receiving enteral and parenteral nutrition support; 10) contraindications to MRI and other examinations; 11) Alcoholism; 12) currently pregnant or planning to become pregnant within the follow year; currently lactating; 13) participated in a clinical trial using the investigational drug or device within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| muscle strength; | — |
Secondary
| Measure | Time frame |
|---|---|
| body composition;serum vitamin k2;serum dp-ucMGP;ABI;baPWV;Head MRI;carotid artery ultrasound;serum Zinc;oral microbiome;Mini-Mental State Examination,MMSE;Hospital Anxiety and Depression Scale,HADS;Pittsburgh sleep quality index, PSQI;Fugl-Meyer assessment scale,FMA;Medical Outcomes Study 36-Item Short Form Health Survey,SF-36;serum biochemical indices;NIH Stroke Scale, NIHSS;Modified Rankin scale grade,MRSG;Exercise capacity testing; | — |
Countries
China
Contacts
Public ContactLi Ying
Harbin Medical University
Outcome results
None listed