End-stage renal disease
Conditions
Interventions
Maintenance hemodialysis group:Observational study, no intervention.
Maintenance hemodialysis combined with heart failure group:Observational study, no intervention.
Control group:Observational study, no intervention.
Sponsors
The First Affiliated Hospital, Xi'an Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 87 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for maintenance hemodialysis group: 1. Over 18 years old; 2. Receive hemodialysis treatment for 1 year or more (3 times a week for more than 4 hours each time); 3. Sign the informed consent form. Inclusion criteria for maintenance hemodialysis combined with heart failure group: 1. Over 18 years old; 2. Receive hemodialysis treatment for 1 year or more (3 times a week for more than 4 hours each time); 3. heart failure diagnosis in accordance with the Chinese Guidelines for the Diagnosis and Treatment of Heart Failure (2018) with reduced ejection fraction (heart failure with preserved ejection (HFpEF) : 1) have symptoms and/or signs of heart failure; 2) Left ventricular ejection fraction (LVEF) < 40%. 4. Sign the informed consent form. Control group inclusion criteria: 1. No obvious disease; 2. Age, sex and case group matched; 3. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria for maintenance hemodialysis group: 1. Kidney transplant patients; 2. Pregnant patients; 3. Receiving antibiotics within the past 3 months; 4. History of infectious diseases in the past 3 months; 5. Have received periodontal treatment in the past 1 year; 6. Unable to obtain informed consent. Exclusion criteria for maintenance hemodialysis combined with heart failure: 1. Kidney transplant patients; 2. Pregnant patients; 3. Receiving antibiotics within the past 3 months; 4. History of infectious diseases in the past 3 months; 5. Have received periodontal treatment in the past 1 year; 6. Unable to obtain informed consent; 7. heart failure with preserved ejection fraction (HFpEF) according to Chinese Guidelines for the Diagnosis and Treatment of Heart Failure (2018) : 1) have symptoms and/or signs of heart failure; 2) LVEF=50%; 3) Increased natriuretic peptides consistent with at least one of the following: ? left ventricular hypertrophy and/or left atrial enlargement; ? abnormal ventricular diastolic function. 8. heart failure with mid-range ejection fraction (HFmrEF) in the Chinese Guidelines for the Diagnosis and Treatment of Heart Failure (2018) : 1) have symptoms and/or signs of heart failure; 2) LVEF 40% ~ 49%; 3) Increased natriuretic peptides consistent with at least one of the following: ? left ventricular hypertrophy and/or left atrial enlargement; ? abnormal ventricular diastolic function. Control group exclusion criteria: 1. Pregnant and lactating women; 2. Lifestyle that significantly affects the microbiota, such as taking drugs in the past month, including antibiotics, metformin, statins, probiotics, and prebiotics; Eat yogurt more than 3 times a week in the past month; Heavy drinking in the past week (drinking more than 4 glasses of white wine at a time, drinking more than 1000ml of beer), or drinking every week in the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral microflora; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oral periodontal status examination and score; | — |
Countries
China
Contacts
Public ContactLi Lu
The First Affiliated Hospital, Xi'an Medical University
Outcome results
None listed