Chronic liver disease
Conditions
Interventions
Group 1:Rapid core biopsy-Uniform cutting biopsy
Group 2:Uniform cutting biopsy-Rapid core biopsy
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age range between 18 and 80 years old; 2.Chronic liver disease meeting the indications for liver biopsy: ? Hepatitis B; ? Fatty liver; ? Autoimmune hepatitis; ? Other chronic liver diseases of unknown origin that benefit from liver biopsy; 3.Ability to tolerate painless endoscopic anesthesia; 4.Patient and family members (guardians) willing to participate in this study, and signing the informed consent form.
Exclusion criteria
Exclusion criteria: Subjects meeting any of the following criteria are not eligible for participation in this study: 1.Inability to tolerate endoscopic examination; 2.Patients with contraindications to endoscopic examination or anesthesia; 3.Coagulation disorders (platelets less than 50*10^9, corrected prothrombin time [PT] greater than 3 seconds above the upper limit of normal); 4.Patients with severe primary diseases such as respiratory, cardiovascular, cerebrovascular, digestive, hematological systems, as well as those with psychiatric or infectious diseases; 5.Imaging suggestive of malignant liver tumors; 6.Patients with confirmed cirrhosis on imaging; 7.Age less than 18 or over 80 years; 8.Pregnant or lactating women; 9.Refusal to participate in the clinical study; 10.Other conditions deemed unsuitable for this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy: sample length, number of complete manifold areas included, and clear diagnostic rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety: adverse event occurrence rate; | — |
Countries
China
Contacts
Public ContactLi Baiwen
Shanghai General Hospital
Outcome results
None listed