anxiety disorder
Conditions
Interventions
"Intelligent Rehabilitation Therapists" intervention group:The intervention consisted of 15-18sessions, each lasting 15 minutes, and was pushed 2-3 times a week for a total of 6 weeks. Interventions i
Intelligent multi-scene mind-body training intervention based on virtual reality (VR):To preliminarily verify the intervention effect of VR based mind-body interactive training in different types of a
Single transcranial direct current stimulation (tDCS) intervention in true stimulation group:tDCS setting: (1)PD patients: a bilateral stimulation mode was adopted, with the anode placed on the left v
(2) GAD patients: a bilateral stimulation mode was adopted, with the anode placed on the left dlPFC and the cathode placed on the right dlPFC. Current of stimulation: 2mA. The study period was divide
Follow-up period: one
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Study 1. Study on the intervention effect of "Intelligent Rehabilitation Therapist" and "Multi-scene Mind-body Interaction Training" : (1) Patients with panic disorder (PD) : Inclusion criteria: I. The diagnosis meets the DSM-5 diagnostic criteria for panic disorder; II. PDSS score > 10; HAMD score 51 points; HAMD-17 score 7 after 4 weeks of effective dose stabilization with at least one antidepressant; HAMD-17 score < 17; III. No gender limitation, age: 18-60 years old; Primary school education or above; IV. Has not received systematic physical therapy; V. Informed consent signed by the patient. 2) Patients with generalized anxiety disorder (GAD) Inclusion criteria: I. Meet the DSM-5 diagnostic criteria for generalized anxiety disorder; II. HAMA score remained higher than 14 points after 4 weeks of effective dose stabilization with at least one antidepressant; HAMD-17 score < 17; III. No gender limitation, age: 18-60 years old, primary school education or above; IV. Has n
Exclusion criteria
Exclusion criteria: Study 1. Study on the intervention effect of "Intelligent Rehabilitation Therapist" and "Multi-scene Mind-body Interaction Training" : Exclusion criteria: I. A current or past diagnosis of another major mental illness that meets the DSM-5 diagnostic criteria, including schizophrenia, bipolar disorder, etc. (other than depressive disorder); II. Currently, there are patients with substance addiction disorders such as alcohol and medicine and non-substance addiction disorders such as online games; III. Currently, researchers with serious physical diseases do not consider it suitable to be included in this study; IV. Any other conditions deemed unsuitable for inclusion by the investigator. Study 1. A randomized controlled study of tDCS intervention in Anxiety Disorder: Exclusion criteria: I. Current or past mental illness that meets the DSM-5 diagnostic criteria (other than aphobia); II. Currently, there are patients with substance addiction disorders such as alcohol and medicine and non-substance addiction disorders such as online games; III. Currently, researchers with serious physical diseases do not consider it suitable to be included in this study; IV. Patients with metal implants and metal dentures in the body, during pregnancy and lactation, claustrophobia and other patients who cannot perform MRI scan; And any other conditions that the researchers deem unsuitable for inclusion. Study 1. Synergistic effect of tDCS on drug therapy in patients with Anxiety disorder: Exclusion criteria: I. Current or past mental illness that meets the DSM-5 diagnostic criteria (other than aphobia); II. Currently, there are patients with substance addiction disorders such as alcohol and medicine and non-substance addiction disorders such as online games; III. Currently, researchers with serious physical diseases do not consider it suitable to be included in this study; IV. Any other conditions deemed unsuitable for inclusion by the investigator. Study two targeted modular integrated intervention cohort study: Exclusion criteria: I. Currently has a major mental illness that meets the diagnostic criteria of DSM-5, including schizoaffective disorder and neurocognitive disorder, schizophrenia, bipolar disorder, and is in the paroxysmal stage; (patients with bipolar disorder in stable stage, and depression disorder, aphobia patients are excluded); II. Patients with current or past drug dependence; III. Suicidal persons; IV. There are currently researchers with serious physical diseases, and other researchers do not consider them suitable for inclusion;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Panic Disorder Severity Scale, PDSS;Hamilton Anxiety Scale, HAMA;Hamilton Depression Scale, HAMD;Liebowitz Social Anxiety Scale, LSAS;Generalized Anxiety Disorder, GAD-7; | — |
Secondary
| Measure | Time frame |
|---|---|
| Social Phobia Scale, SPS;state-trait anxiety inventory - Form, Y-STAI;Anxiety Sensitivity Index-3, ASI-3;Cognitive Emotion Regulation Questionnaire,CERQ;Irrational Beliefs Scale, IBS;Chinese Big Five Personality Inventory brief version;Attention to Positive and Negative Information Scale,APNI;Childhood Trauma Questionnaire, CTQ;Chinese Perceived Stress Scale, CPSS;Self-Rating Anxiety Scale, SAS;Center for Epidemiological Survey,Depression Scale,CES-D;Ruminative Responses Scale, RRS;Life Event Scale,LES;Acceptance and Action Questionnaire-2nd Edition, AAQ-Il;Visual Analogue Scale/Score, VAS;Igroup Presence Questionnaire, IPQ;Clinical Global Impression, CGI;Social Interaction Anxiousness Scale, SIAS;Panic Disorder Severity Scale, PDSS-SF;Wsiconsin card sorting test ,WCST;N-back task;Stop-Signal Task, SST;Dot-probe-task;emotional stroop task; | — |
Countries
China
Contacts
Public ContactLi Zhanjiang
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed