Diseases of the respiratory system
Conditions
Interventions
Case series:none
Sponsors
Sichuan University, West China Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with asthma • Age= 18 years, regardless of gender; • The diagnostic criteria for asthma are in line with GINA and China's guidelines for asthma diagnosis and treatment; • In the stable stage of asthma, i.e., no change in maintenance treatment regimen in the 4 weeks prior to enrollment, no respiratory tract infection or/and asthma exacerbation; • Voluntarily participate and sign the informed consent form. Inclusion criteria for patients with severe asthma (SA). • Confirm evidence of any of the following variable airflow obstruction (VAO) at the screening visit or in the last 10 years of medical records: including: 1. Positive Bronchial Challenge Test (BCT): FEV1 decreased by =20% compared with before bronchial provotion; 2. Positive Bronchial Dilation Test (BDT): FEV1 increased by =12% compared with before bronchodilator, and its absolute value increased by =200ml; 3. Peak expiratory flow rate (PEF) variability > 12%, monitored for at least 1 week; 4. FEV1 mutation rate>12% (between 2 measurements within 2 months); • Patients are unable to achieve asthma control despite the use of GINA grade 4-5 recommended therapy (eg, high-dose ICS, budesonide > 800 µg, fluticasone > 500 µg); • Asthma control can only be maintained with the recommended treatment of GINA grade 4-5 such as high-dose ICS, budesonide >800 µg, fluticasone >500 µg); Inclusion criteria for patients with non-severe asthma (NSA). • Use of maintenance doses of inhaled controlled therapeutic drugs; • Asthma is under control, i.e. ACQ 20;
Exclusion criteria
Exclusion criteria: • Those who have undergone heart, lung or thoracic surgery; • Pregnant or lactating women; • Those who cannot cooperate with sputum induction and pulmonary function operators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endotracheal intubation; | — |
Countries
China
Contacts
Public ContactDeYing Kang
Sichuan University, West China Hospital
Outcome results
None listed