Sleep disturbances
Conditions
Interventions
experimental group:esketamine
Control group:saline
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1)Age 18-65 years old, (2)ASA (American Society of Anesthesiologists) grade I-?, (3)Patients with the preoperative PSQI >5, (4)Elective laparoscopic surgery.
Exclusion criteria
Exclusion criteria: (1)Cognitive dysfunction or inability to communicate, (2)Patients with mental illness, (3)Patients with contraindications to anesthetic use, (4)Recent history of substance abuse, (5)Patient refusal to participate in the study, (6)Body mass index (BMI) > 30 kg/m2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative sleep disturbance on postoperative day 1; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative static and dynamic pain NRS scores;Postoperative opioid consumption;postoperative anxiety and depression scores;Incidence of PSD on postoperative day 3,7;Sleep quality (NRS) score on 1 day preoperatively and on day 1, 3, and 7 postoperatively;Christense Postoperative Fatigue Scale;Oral saliva flora and metabolites on the morning of the day of surgery and the first morning after surgery;AIS scores on the first, third and seventh day after surgery; | — |
Countries
China
Contacts
Public ContactYang Jianjun
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed