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Analgesic effects of High-Definition Transcranial Random Noise Stimulation Targeting the Primary Motor Cortex

Analgesic effects of High-Definition Transcranial Random Noise Stimulation Targeting the Primary Motor Cortex

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400079629
Enrollment
Unknown
Registered
2024-01-08
Start date
2024-02-01
Completion date
Unknown
Last updated
2024-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain

Interventions

1:Current 1 mA, -250µA per return electrode
frequency 0-650Hz
DC-offset 1 mA (-250µA per return electrode)
stimulation time 20min
2:Current 1.5 mA, -250µA per return electrode
stimulation time 20min.
3:Current 2 mA, -250µA per return electrode
4:DC current during sham stimulation was also increased in a ramp-like manner for 30 s until reaching 1 mA. The current intensity then gradually decreases (ramps off) over 30 seconds until it switches

Sponsors

Shanghai University of Sport
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: (1) Aged between 18-35 years old; (2) The construction of capsaicin-induced pain model can be achieved; (3) No sports-specific or professional athletes; (4) Body mass index between 18-23.9kg/m2; (5) Right-handed; (6) Vision or corrected-to-normal vision is normal; (7) Be physically and mentally healthy, have normal cognitive abilities, and be able to successfully complete this experiment; (8) No persistent or intermittent body pain in any of the past 3 months, and no abnormal sensation in the waist and limbs; (9) No habit of smoking, drinking, regularly taking sleeping pills, analgesics and other drugs; (10) Subjects voluntarily participate and sign informed consent;

Exclusion criteria

Exclusion criteria: (1) Women are in menstruation or pregnancy; (2) Received neuromodulation intervention such as transcranial electrical stimulation or transcranial magnetic stimulation within the past 3 months; (3) There are metal implants on the head or metal implants such as heart stents and pacemakers in the body; (4) Mental illness such as depression, schizophrenia or autism, regular use of opioids or antipsychotics; (5) Any neurological or musculoskeletal disease, especially epilepsy, stroke, brain trauma or migraine, as well as diseases that affect sensory processing, such as diabetes; (6) There are other acute symptoms on the day of the experiment, such as colds, fever, etc.

Design outcomes

Primary

MeasureTime frame
pressure pain threshold;conditioned pain modulation;heat pain threshold;

Secondary

MeasureTime frame
pain empathy test;Attention network test;functional near-infrared spectroscopy;

Countries

China

Contacts

Public ContactWang Xueqiang

Shanghai University of Sport

qiang897@163.com+86 188 5435 9605

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026