Ureteral /kidney calculi
Conditions
Interventions
lidocaine group:Lidocaine was given 1.5 mg·kg-1 lidocaine at the time of anesthesia induction
normal saline group:Normal saline was administered intravenously during induction
Sponsors
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Prior to the initiation of any trial-related activities, the subject shall obtain informed consent, fully understand the purpose and significance of the trial, and be willing to comply with the trial protocol; 2) patients aged 18-60 years; 3) American Society of Anesthesiologists (ASA) grade I-II; 4) subjects undergoing transurethral ureteropelvic laser lithotripsy general anesthesia; 5)body mass index of 19-25 kg/m2.
Exclusion criteria
Exclusion criteria: 1) Difficult airway and severe respiratory diseases, acute respiratory infections, uncontrolled asthma and unexplained dyspnea; 2) Subjects with mental system diseases and cognitive dysfunction and a history of epilepsy; 3) Subjects with cardiovascular diseases (such as congenital heart disease, bradycardia requiring treatment, hypotension requiring treatment, etc.); 4) Subjects with abnormal liver function, alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) exceeding 1.5 times the upper limit of normal; Subjects whose total bilirubin exceeds the upper limit of normal; Subjects with abnormal renal function and blood creatinine exceeding the upper limit of normal; 5) Abnormal plasma cholinesterase activity or pseudocholinesterase deficiency; 6) Participated in other clinical trials (received experimental drug or placebo) within 3 months before surgery; 7) Long-term use of drugs that affect muscle nerve conduction and allergic to narcotic drugs; 8) Other conditions deemed unsuitable for participation in this clinical trial by the investigator. 9) The method of anesthesia was changed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the onset time;train–of–four recover to 25 %;recovery index; | — |
Secondary
| Measure | Time frame |
|---|---|
| vital signs;General information included age, sex, body mass index, and duration of surgery;Coughing, body movement, laryngeal spasm and bronchospasm during laryngeal mask placement;Incidence of skin flushing and decreased blood pressure; | — |
Countries
China
Contacts
Public ContactShangguan Wangning
Wenzhou Medical University Affiliated Stomatological Hospital
Outcome results
None listed