sleep disorders after general anesthesia
Conditions
Interventions
Control group:0.5ug/kg was used before the operation and dexmedetomidine was not used in the postoperative analgesic pump
Intervention group:0.5ug/kg was used before the operation and dexmedetomidine 1.2ug/kg/d was added to postoperative analgesia pump for 48h
Sponsors
The affiliated Suzhou hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients with general anesthesia for elective surgery (2) The patient voluntarily participated in the trial and signed the informed consent
Exclusion criteria
Exclusion criteria: (1) Presence of sick sinus syndrome, severe bradycardia (heart rate<50/min) or more than second degree atrioventricular block, permanent pacemaker implantation, severe heart failure, or ejection fraction<30% of patients (2) Patients with severe liver and kidney dysfunction (Child-Pugh B and C, CKD3-5) (3) patients with central nervous system diseases (4) Patients with sleep apnea syndrome and other types of sleep disorders (5) patients scheduled to be admitted to ICU after surgery and patients not scheduled to be admitted to ICU (6) Patients allergic to dexmedetomidine (7) Patients and their families refused to participate in the study (8) Patients with severe dementia, low cognitive function, language disorder, severe hearing or vision impairment, mental disorder, coma and other conditions that can not complete the assessment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective sleep improvement ;Objective sleep improvement 48 hours after surgery ; | — |
Secondary
| Measure | Time frame |
|---|---|
| preoperative and postoperative anxiety states;delirium at 48h hours after surgery;pain score of 48h postoperatively ;nausea and vomiting;length of stay in hospital;CRP;IL-6;IL-18;IL-1ß;TNF-a; | — |
Countries
China
Contacts
Public ContactYumin Zhu
The affiliated Suzhou hospital of Nanjing Medical University
Outcome results
None listed