Stsegment Elevation Myocardial Infarction
Conditions
Interventions
disease-affected meridian (DAM) group:The DAM group acupoints include CV14 (Juque), CV4 (Guayuan), and bilateral PC6 (Neiguan), L14(Hegu), ST36 (Zusanli), LR 3(Taichong).
non-affected meridian (NAM) group:The NAM group acupoints include bilateral acupoints LU9 (kongzui) and LU6 (Taiyuan)
Sponsors
Heart Center, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria (1) Aged 18-75 years. (2) First medical contact=12 hours. (3) Diagnosis of Anterior STEM: Patients admitted with criteria for anterior STEMI according to the fourth universal definition of myocardial infarction[21]. New ST-elevation at the J-point in 2 contiguous leads with the cut-point: =1 mm in precordial leads other than leads V2–V3 where the following cut-points apply: =2 mm in men =40 years; =2.5 mm in men 90U (6) Consent to participate.
Exclusion criteria
Exclusion criteria: (1) Prior angina pectoris, myocardial infaction, or revascularization (PCI or CABG) (2) Severe cardiac insufficiency or hypotension (systolic blood pressure 3-fold ULN; eGFR<30ml/min/1.73mm2) (6) Patients with end-stage diseases (such as untreatable malignancies) and a life expectancy of less than 1 year (7) Pregnancy, lactation, or potentially fertile women (8) Allergy to any medication used in hospital (9) Participating in other interventional clinical trial or the investigator considers it inappropriate to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CK-MB;Area under the curve (AUC) of serum CK-MB release; | — |
Secondary
| Measure | Time frame |
|---|---|
| ST segment resolution;Myocardial flow reserve;cardiac functional parameters (left ventricular ejection fractions, speckle tracking, longitudinal strain);inflammatory factors (IL-6, hs-CRP, and TNF-a);markers of endothelial injury (ET-1, vWF, and P-selectin);Major adverse cardiovascular events within 6 months;Questionnaire of quality of life:;any adverse events;serious adverse events; | — |
Countries
China
Contacts
Public ContactXiaowei Niu
First Hospital of Lanzhou University
Outcome results
None listed