Ventilator-associated pneumonia
Conditions
Interventions
Intervention Group ?:Negative pressure suction toothbrush and 0.12% chlorhexidine
Intervention Group ?:Negative pressure suction toothbrush and 2% chlorhexidine
Control group:Negative pressure suction toothbrush + saline solution
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age =18 years old; (2) Expected mechanical ventilation time =48h; (3) no known oral diseases;
Exclusion criteria
Exclusion criteria: (1) Pulmonary infection occurred 48 hours before enrollment; (2) previous underlying lung diseases; (3) The patient had no teeth; (4) Have been intubated =48h before admission or have a recent history of intubation; (5) Known allergy to chlorhexidine; (6) Have participated in other interventional clinical studies; (7) Refuse to participate in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of ventilator-associated pneumonia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of oral colonies;Incidence of oral adverse events;Days of mechanical ventilation;Length of ICU stay;28-day all-cause mortality; | — |
Countries
China
Contacts
Public Contacthufen
Zhongnan Hospital of Wuhan University,
Outcome results
None listed