mild cognitive impairment(MCI)
Conditions
Interventions
Health group -1:The healthy group 1 first performed the "motor cognition dual task" and intervened for 30 minutes (once in total). FNIRS brain function and Gaitrite gait parameters were collected simu
Health group -2:The healthy group 2 first performed the "dual task of synchronous movement cognition of head needle" and interfered for 30 minutes (once in total). FNIRS brain function and Gaitrite ga
MCI-1:MCI-1 was subjected to "dual task of synchronous movement cognition of head needle" training, and the intervention lasted for two weeks, five times/week, 30 minutes/ time. fNIRS brain function c
MCI-2:MCI-2 was trained with a "dual task of motor cognition" training, the intervention lasted for two weeks, five times/week, 30 minutes/ time. During the inte
Sponsors
The Fifth Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: Healthy subjects: ? The age is 20-80 years old (including 20 and 80 years old); ? MMSE is consistent with normal cognitive level; ? MoCA is consistent with normal cognitive level; ? no aphasia; ? no history of mental illness; ? No obvious organ function injury: including congestive heart failure, lower extremity deep vein thrombosis, malignant progressive hypertension, respiratory failure; Active liver disease, hepatic and renal insufficiency. ? Sign informed consent voluntarily. Patients with MCI: ? Age 50-80 years old (including 50 and 80 years old); ? can walk independently without assistance (assistance includes: crutches or walking frames); ? Clinical Dementia Rating Scale (CDR) score was 0.5; ? Sign informed consent voluntarily; ? Meet the clinical diagnostic criteria for MCI: patients or informed persons report, or experienced clinicians find cognitive impairment; Objective evidence of impairment in one or more domains of cognitive function: memory, executive function, attention, and language; Complex instrumental daily abilities may be slightly impaired, but the ability to maintain independent daily living; The diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5) has not yet met the diagnostic criteria for dementia. ? Patients with no obvious organ function impairment included congestive heart failure; Lower extremity deep vein thrombosis; Malignant progressive hypertension; Respiratory failure; Active liver disease; Liver and kidney dysfunction.
Exclusion criteria
Exclusion criteria: The following exclusion criteria were used in both groups: ? Pregnant and lactating women; ? There are diseases affecting gait, such as hemiplegia, Parkinson's disease, fracture, knee joint disease, lower limb joint injury, etc. ? A history of mental illness or use of antipsychotic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gaitrite Gait analysis parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| fNIRS index of brain function; | — |
Countries
China
Contacts
Public ContactYuanyuan Guo
The Fifth Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed