schizophrenia
Conditions
Interventions
Working memory training group:Working memory training+Routine clinical interventions
Intermittent theta burst stimulation and work memory group :Intermittent theta burst stimulation and Work memory training + Routine clinical interventions
Sponsors
West China Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-60 years old; 2) Conforming to the diagnostic criteria for schizophrenia in the fourth edition of the Diagnostic and Statistical Manual for Mental Disorders, diagnosed by a psychiatrist based on MINI plus v 5.0, with a course of at least 1 year; 3) Patients who have received stable dose medication in the past month and have significant negative symptoms: the negative symptom score on the Positive and Negative Symptom Scale (PANSS) is not less than 20, and at least one item on the PANSS negative symptom scale is = 4 points; 4) All patients have stable clinical conditions and are able to provide informed consent, and all participants have obtained written informed consent; 5) Take second-generation antipsychotic drugs, such as Olanzapine and Quetiapine.
Exclusion criteria
Exclusion criteria: 1) Merge with other brain diseases; 2) Severe physical conditions, including severe liver, kidney, cardiovascular and other diseases; 3) History of alcohol and drug abuse; 4) Individual or family medical history of other mental diseases, including Personality disorder and mental retardation; 5) People with metal clips, plates, or any other metal objects on their heads; 6) Receiving electroconvulsive treatment within 6 months; 7) The evaluation and treatment process do not cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psychopathological status;Negative symptoms ;Oxyhemoglobin in brain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function;CDSS assess the patient’s depression ;Patient‘s social function; | — |
Countries
China
Contacts
Public ContactZhangWei
West China Hospital
Outcome results
None listed