Clinical characteristics and endotypes of chronic sinusitis associated with HIV Infection

Endotype study and efficacy prediction value analysis of chronic sinusitis associated with HIV Infection

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400079507

Enrollment

Unknown

Registered

2024-01-04

Start date

2024-01-15

Completion date

Unknown

Last updated

2025-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acquired Immunodeficiency Syndrome

Interventions

Chronic sinusitis associated with HIV Infection group:None

CRS without combined special infections group:None

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Chronic sinusitis associated with HIV Infection: 1. Aged 18 to 65 years; 2. The diagnosis of chronic sinusitis meets the criteria of the Chinese Guidelines for the Diagnosis and Treatment of Chronic Nasal Sinusitis (2018); 3. The diagnosis of AIDS is in line with the Guidelines for AIDS Diagnosis and Treatment in China (2021). CRS without combined special infections: 1. Aged 18 to 65 years; 2. The diagnosis of chronic sinusitis meets the criteria of the Chinese Guidelines for the Diagnosis and Treatment of Chronic Nasal Sinusitis (2018); 3. No combined infectious diseases such as AIDS, viral hepatitis and syphilis.

Exclusion criteria

Exclusion criteria: 1.Subjects who have required a burst of oral corticosteroids or immunotherapy within the 3 months, or nasal spray corticosteroids or antibiotics or anti-leukotrienes within 4 weeks before screening; 2.Subjects with other nasal diseases, such as primary ciliary dyskinesia; 3.Subjects with sinus surgeries in the past 6 months; 4.Subjects with other chronic diseases such as autoimmune diseases, malignant tumors ; 5.Subjects with a history of parasitic infection, or chronic infectious diseases such as viral hepatitis and syphilis, especially those who have not received standardized treatment; 6.Subjects with acute sinusitis or acute sinusitis or acute upper respiratory tract infection within 4 weeks of the screening visit ; 7.Women who are pregnant, breast-feeding.; 8. Poor compliance: Subjects who are unable to cooperate with the experiment.

Design outcomes

Primary

Measure	Time frame
Visual analogue scale for sinusitis; 22 nasal and sinuses outcome tests;Lund-Kennedy score;	—

Secondary

Measure	Time frame
Lund -- Mackay score was scanned by sinus CT;Endotypes of nasal sinusitis tissues;Prognosis evaluation at 6 months after surgery;	—

Countries

China

Contacts

Public ContactShao Shan

Beijing You 'an Hospital, Capital Medical University

shans817@163.com+86 186 1812 8170

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026