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A randomized, single blind, single center clinical study on the mechanism of Xiongzhi Tongluo Capsule in the treatment of diabetes nephropathy by inhibiting the related pathway of scorch death

Study on the mechanism of Xiongzhi Tongluo Capsule in the treatment of diabetes nephropathy by inhibiting the related pathway of scorch death

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400079474
Enrollment
Unknown
Registered
2024-01-04
Start date
2024-01-07
Completion date
Unknown
Last updated
2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetic kidney disease

Interventions

therapy group:Basic treatment + Xiongzhi Tongluo Capsules 6 capsules 3 times a day
control group:Basic treatment

Sponsors

Hebei Yiling Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1) Type 2 diabetes patients; 2) Age range from 40 to 85 years old, regardless of gender; 3) Estimated glomerular filtration rate (eGFR)>15 ml/min/1.73 m2 (CKD-EPI formula); And or 24 hour urine protein quantity>0.5g or kidney disease symptoms in patients with diabetes and kidney disease; 4) Able to understand the procedures and methods of this clinical study, correctly express willingness, voluntarily participate and sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1) Non T2DM patients; 2) T2DM patients with known malignant tumors, or lactic acidosis, or ketoacidosis, or severe infections, or critically ill patients (such as organ failure, heart failure, myocardial infarction, cerebral infarction, etc.); 3) Have a history of primary thyroid disease and thyroid autoimmune disease.

Design outcomes

Primary

MeasureTime frame
Pyrosis associated proteins (GSDMD, caspase-1, IL-1) ß, IL-18);Urinary protein creatinine ratio;glomerular filtration rate;

Secondary

MeasureTime frame
renal function;blood fat;Coagulation indicators;blood sugar;Blood routine;

Countries

China

Contacts

Public ContactLi Huifang

Hebei Yiling Hospital of Hebei Medical University

huifangli2612@126.com+86 189 3272 2069

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026