post-stroke dysphagia
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) the patients met the diagnostic criteria for stroke diagnosis and efficacy evaluation, diagnostic criteria for various cerebrovascular diseases, and the consensus of experts in the evaluation and treatment of swallowing disorders in China (2017 version); (2) the life signs were stable after regular treatment and the course of the disease was less than 3 months; (3) the patients had the clinical manifestations of dysphagia and cough after drinking water; (4) dyskinesia of soft palate, pharynx, tongue, the masseter or facial muscles, no atrophy of tongue muscle and tremor of tongue muscle; (5) physiological brainstem reflex: existence or hyperactivity of soft palate reflex, hyperactivity of mandibular reflex. The pathological brainstem reflex was positive; (6) Those who voluntarily participate in this clinical trial, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) cases of large-area cerebral infarction and severe cerebral hemorrhage; (2) cases of true bulbar paralysis; (3) cases of pseudobulbar paralysis over 90 days; (4) cases of disturbance of consciousness; (5) cases of cognitive dysfunction; (6) patients with severe multiple organ dysfunction syndrome, (7) patients who failed to complete the acupuncture treatment according to the experimental plan, (8) patients who had contraindications to MRI examination such as claustrophobia and metal implants; (9) severe asymmetry of cranial anatomy or definite lesions were found in MRI scan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| water swallow test and Blood oxygen saturation detection;Standard Swallowing Function Assessment Scale (SSA);Videofluorographic swallowing study score;Detection of monoamine neurotransmitter content [?- Aminobutyric acid (GABA), glutamic acid (GA), acetylcholine receptor (AChR), 5-hydroxytryptamine (5-HT), acetylcholine (ACh), norepinephrine (NE), dopamine (DA)];Evaluation of cortical medullary tract brain DTI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immune function and nutritional indicators (TLC, IgG, IgA, Hb, ALB, STP);Effective rate;incidence of adverse reactions;clinical symptoms and signs of patients; | — |
Countries
China
Contacts
The Second Affiliated Hospital of Anhui University of Chinese Medicine