A Study on the Correlation between Damp-Heat Syndrome of Wilson's Disease and Liver, Brain Function Based on Multi-omics

The correlation between liver and brain function with dampness-heat syndrome in Wilson disease by omics for transcription, protein and imaging

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400079449

Enrollment

Unknown

Registered

2024-01-03

Start date

2024-01-03

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatolenticular degeneration/Wilson disease

Interventions

Observation group:none

Control group:none

Eligibility

Sex/Gender

All

Age

10 Years to 60 Years

Inclusion criteria

Inclusion criteria: ? The clinical diagnosis was Wilson's disease; ? WD patients with damp-heat intrinsic syndrome were classified by TCM syndrome differentiation; ? Voluntary signing of informed consent form

Exclusion criteria

Exclusion criteria: ? Patients with severe liver failure; ? Patients with serious complications; ? Patients with other diseases; ? The researchers believe that subjects with other unsuitable factors for participating in this experiment.

Design outcomes

Primary

Measure	Time frame
transcriptomics;proteomics;Brain MRI+DWI+ADC sequence;Liver MRI+DWI+ ultrasound;the Unified Wilson Disease Rating Scale;Serum copper and 24h urine copper;	—

Secondary

Measure	Time frame
semi-quantitative image rating Scale for WD;Blood biochemical indicators;4 items for Liver fibrosis;	—

Countries

China

Contacts

Public ContactHan Yongsheng; Wang Shijing

Institute of Neurology, Anhui University of Chinese Medicine; Hospital Affiliated to the Institute of Neurology, Anhui University of Chinese Medicine

hyssp@126.com+86 138 6615 9323

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026