Epilepsy
Conditions
Interventions
Experimental group:Take prampanel
Sponsors
Shandong First Medical University affiliated Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Age =18 years old; 2) Epilepsy appeared 1 week after stroke, and there was no history of epilepsy before stroke, and seizures caused by other diseases of the brain and systemic diseases were excluded; 3) Meet the diagnostic criteria for focal epilepsy or bilateral tonic-clonic seizures secondary to focal epilepsy set by the International League against Epilepsy in 2017; 4) Seizures were not controlled during baseline when the patient was treated with a fixed and stable dose ASMs regimen; 5) The patients signed the informed consent and voluntarily participated in the study.
Exclusion criteria
Exclusion criteria: 1) Patients who did not enter the hospital directly; 2) Patients with missing clinical records; 3) Patients with malignant tumors or degenerative diseases of the central nervous system; 4) Patients with mental or intellectual disabilities; 5) Failure to follow up patients; 6) Patients with abnormal liver and kidney function
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The frequency of seizures decreased by =50% after 12 months of treatment compared with before treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| The frequency of seizures decreased by =50% after 6 months of treatment compared with before treatment;Drug retention rate at 3 months;Drug retention rate at 6 months;Final maintenance dose of prampanel;The frequency of seizures decreased by =50% after 3 months of treatment compared with before treatment; | — |
Countries
China
Contacts
Public ContactXuewu Liu
Shandong First Medical University affiliated Provincial Hospital
Outcome results
None listed