Major depressive disorder
Conditions
Interventions
Pharmacogenetic guided treatment group:Pharmocogenetic testing
Treatment as usual:Treatment as ususal
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
8 Years to 55 Years
Inclusion criteria
Inclusion criteria: aged 8-55; Chinese Han population; Outpatient or inpatient patients; Diagnosed as depression by two or more psychiatrists, with a baseline Hamilton Depression Scale (HAMD-17) of = 18; Having a fixed residence, able to complete a 12 week acute phase treatment follow-up, and agreeing to cooperate with the researcher to complete the treatment follow-up on time; Understand the research content and sign an informed consent form.
Exclusion criteria
Exclusion criteria: Suffering from serious physical diseases (such as metabolic diseases, kidney diseases, liver diseases, thyroid diseases, etc.) or organic brain diseases, can refer to laboratory abnormal indicators with a normal value of more than twice or combine with the opinion of the research doctor; A history of consciousness loss exceeding 5 minutes; Have a history of alcohol or substance abuse/dependence within the past year; Has undergone electroconvulsive therapy within the past six months; Regular use of addictive drugs within the past month; There are other mental disorders (personality disorders and mental retardation) that significantly affect the patient's current mental state; Those who currently have serious impulses, self harm, or attempted suicide; Pregnant or lactating women, or those planning to conceive; The researchers believe that there are situations that do not comply with the clinical study, or compliance cannot meet the follow-up requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-17 total score reduction rate;cognitive valuation (MMSE);rate of adverse reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| effective rate ;remission rate;cognitive valuation (MOCA); | — |
Countries
China
Contacts
Public ContactChunhua Zhou
The First Hospital of Hebei Medical University
Outcome results
None listed