cholecystectomy
Conditions
Interventions
control group:Equal dose of normal saline was given before incision
esketamine group:0.3mg/kg esketamine was given before incision
Sponsors
Xiangyang Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) ASA grade ?-?; 2) Age =18 years old, weight 50-100kg, gender unlimited; 3) Patients undergoing cholecystectomy under general anesthesia; 4) Sign informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1) Known allergy to the active ingredients or excipients of esketamine hydrochloride injection; 2) suffering from severe cardiovascular and cerebrovascular diseases, respiratory diseases, blood diseases, endocrine diseases or liver and kidney dysfunction; 3) Increased risk of intraocular pressure (such as glaucoma), and intracranial pressure; 4) Combined with neurological or mental illness; 5) alcoholism or long-term use of sedatives and analgesics; 6) Patients who have undergone surgery or used experimental drugs within one week before surgery; 7) Participants who have participated in clinical trials of other drugs as subjects in the past 3 months; 8) Communication barriers (reading and writing Chinese barriers, language barriers, visual impairments or hearing impairments, etc.) can not cooperate with the completion of the research; 9) Those who refuse to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| biliary-cardiac reflex ;VAS pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative changes of blood pressure, heart rate and oxygen saturation;Postoperative opioid requirement;Preoperative and postoperative depression/anxiety (Hospital Anxiety and Depression Scale-HAD Scale) and cognitive function scores (Simple Intelligent Mental State Examination Scale (MMSE)); | — |
Countries
China
Contacts
Public ContactYexihong
Xiangyang Central Hospital
Outcome results
None listed