Explore the effects of high-frequency repetitive transcranial magnetic stimulation coupled with visual feedback cycling training on lower extremity motor function and potential neural mechanisms in stroke patients

The effects of cycling training induced by high-frequency repetitive transcranial magnetic stimulation on lower extremity motor function in stroke patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400079360

Enrollment

Unknown

Registered

2024-01-02

Start date

2024-01-02

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Combination Group:Simultaneous high frequency rTMS applied to bilateral M1 during a 15-minute visual feedback cycling training

Sham Group:Sham rTMS applied to bilateral M1 during a 15-minute visual feedback cycling training

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) First-time occurrence of a unilateral supratentorial stroke confirmed by computed tomography (CT) or magnetic resonance imaging (MRI) ; (2) Time after onset of stroke of more than 1 months; (3) Brunnstrom recovery stage of the lower limb = 4 stage; (4) Ability to stand independently more than 10 seconds and walk more than 2 minutes with/without the use of canes.

Exclusion criteria

Exclusion criteria: (1) The Wasserman guidelines suggest contraindications for rTMS, such as pacemakers, intracranial implants, drug pump implants, pregnancy, etc; (2) Lower extremity dysfunction caused by reasons other than stroke; (3) Use of neuropsychotropic drugs such as antidepressants or benzodiazepines; (4) Injecting botulinum toxin into lower limb muscles within the past three months; (5) Severe aphasia, apraxia, or cognitive impairment, unable to understand and cooperate in executing instructions; (6) Presence of severe pulmonary and cardiovascular diseases, liver and kidney failure, or malignant tumors, etc.

Design outcomes

Primary

Measure	Time frame
Fugl-Meyer Assessment-Upper Extremity;Berg Balance Scale;10-second standing balance test;2-minute walk test;Hemodynamic response;Motor-evoked potentials, MEP;Cycling training performance;The lower limb strength symmetry;Time up and go test;Cardiopulmonary exercise test;	—

Secondary

Measure	Time frame
Modified Barthel Index;Modified Ashworth Scale;functional ambulation category scale;	—

Countries

China

Contacts

Public ContactZhongli Jiang

Department of Rehabilitation Medicine, Sir Run Run Hospital, Nanjing Medical University

jiangzhongli@njmu.edu.cn+86 138 5189 8370

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026