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Study on the Different Effects of Cocktail Injection Therapy with Different Concentrations and Volumes of the Same Drug on Knee Joint Function After total knee arthroplasty

Study on the Different Effects of Cocktail Injection Therapy with Different Concentrations and Volumes of the Same Drug on Knee Joint Function After total knee arthroplasty

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400079342
Enrollment
Unknown
Registered
2024-01-01
Start date
2024-01-01
Completion date
Unknown
Last updated
2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Interventions

A experimental group:Cocktail injection therapy with ropivacaine injection 200mg+ketorolac tromethamine injection 30mg+0.9% sodium chloride injection 20ml
B experimental group:Cocktail injection therapy with ropivacaine injection 200mg+ketorolac tromethamine injection 30mg+0.9% sodium chloride injection 40ml

Sponsors

Shengjing Hospital Affiliated to China Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients who underwent artificial total knee arthroplasty due to unilateral knee osteoarthritis in the Spinal Joint Surgery Department of Shengjing Hospital Affiliated to China Medical University from January 1, 2024 to August 31, 2026; Patients with complete preoperative and postoperative clinical and imaging data and signed informed consent forms

Exclusion criteria

Exclusion criteria: Patients who are allergic to the drugs used in this study; Patients with severe knee joint deformity (valgus or varus deformity = 30 °); Patients with a history of knee joint surgery or infection; Patients who have been using opioid drugs for a long time; Patients with severe organ dysfunction who are unable to tolerate surgery; Patients with abnormal coagulation function; Cancer patients; Mental illness patients; Patients who refuse to sign informed consent forms

Design outcomes

Primary

MeasureTime frame
Circumferential diameter of the knee joint on the surgical side;Pain rebound time;

Secondary

MeasureTime frame
Knee joint range of motion (ROM);VAS scores;AKS scores;

Countries

China

Contacts

Public ContactYe Tian

Shengjing Hospital Affiliated to China Medical University

tiany3@sj-hospital.org+86 189 4025 8942

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026