Mild cognitive impairment combined with nocturia
Conditions
Interventions
MCI-nocturia group:None
MCI-non-nocturia group:None
Sponsors
Shenzhen Baoan District People's Hospital(The Second Affiliated Hospital of Shenzhen University)
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for MCI-nocturia group: (1) Meeting the diagnostic criteria for both mild cognitive impairment and nocturia; (2) Age 60 years or older; (3) Montreal Cognitive Assessment Scale score = 26; (4) Pittsburgh Sleepiness Scale score = 5; (5) Signed informed consent and voluntary participation. Inclusion criteria for the MCI-non-nocturia group (1) Age 60 years or older; (2) Montreal Cognitive Assessment Scale score = 26; (3) Nocturnal urination = 1 time; (4) Pittsburgh Sleepiness Scale score = 5; (5) Signed informed consent and voluntary participation.
Exclusion criteria
Exclusion criteria: MCI combined with nocturia group exclusion criteria. (1) Sleep apnea; (2) Severe urinary incontinence (e.g., need for nocturnal protective clothing), indwelling urinary catheters, uremia, and those with urinary tract infections; (3) Poorly controlled type 1 or type 2 diabetes mellitus (e.g., condition is untreated or has required a change or adjustment in medication within the past 30 days); (4) Urinary tract infection in the past 2 weeks; (5) Self-reported irritable thirst (excessive fluid intake, more than 3 cups [24L]/2 hours) or feeling extremely thirsty and drinking large amounts of fluids not related to exercise within the past 12 weeks; (6) Those with a history of stroke such as cerebral infarction cerebral hemorrhage, subarachnoid hemorrhage, etc., within the past year or with a combination of serious systemic diseases such as cardiovascular, cerebrovascular, hematopoietic, or other systemic diseases; (7) Previous history of prostate, urethra or bladder surgery, bladder or prostate tumor; (8) Anxiety and depression; (9) Those with communication disorders such as intellectual disability or unfavorable speech. Exclusion criteria for the control group (1) Severe psychosomatic systemic diseases, anxiety disorder, depression, etc; (2) Diabetes mellitus or acute metabolic complications of diabetes mellitus or history of severe diabetic ketoacidosis, hypoglycemic coma; (3) Comorbid serious primary diseases, such as cardiovascular, cerebrovascular, hepatic, renal and hematologic disorders; (4) Taking drugs that affect cognition (antipsychotics, benzodiazepines, etc.); (5) Epilepsy or a family history of epilepsy, hypothyroidism or some other factor that may affect cognitive function; (6) Those who are unable to complete the assessment of indicators, such as severe aphasia, audiovisual impairment, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Scale (Moca);Nocturia Quality of Life Questionnaire (N-QOL) scores;24-hour urination diary;electroencephalogram index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale (HAMD);Hamilton Depression Rating Scale;Pittsburgh Sleep Quality Index ; | — |
Countries
China
Contacts
Public ContactXingchen Zhou; Shangjie Chen
Shenzhen Baoan District People's Hospital(The Second Affiliated Hospital of Shenzhen University)
Outcome results
None listed