Research and demonstration of nutritional efficacy of probiotics and whey protein powder combined with enteral nutrition for patients with neurological several illness

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300079322

Enrollment

Unknown

Registered

2023-12-30

Start date

2022-04-20

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurological severity

Interventions

A group:Enteral nutrition preparations+use of probiotics starting from the first day of enrollment

B group:Enteral nutrition preparations+starting to use probiotics at AGI level 1

C group:Enteral nutrition preparations+use of probiotics starting from the first day of enrollment+whey protein powder

D group:Enteral nutrition preparations+use of whey protein powder starting from the first day of enrollment

control group:Enteral Nutritional Suspension(SP)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Age: 18-80; (2) Body mass index (BMI) 18.5~24.0kg/m2; (3) When the patient was admitted to the hospital, oral intake was difficult and consciousness was impaired, that is, Glasgow Coma Scale (GCS) = 12 points, or swallowing disorders, Wada drinking water test score = 3 points; (4) Nutrition Risk Screening 2002 (NRS2002) score = 3; (5) Acute gastrointestinal injury (AGI) is 0-1 grade; (6) The implementation of enteral nutrition and supplementation of microecological agents and whey protein powder lasted for more than 2 weeks.

Exclusion criteria

Exclusion criteria: (1) Unstable vital signs of patients: such as respiratory dysfunction (PO260mmHg), cardiovascular dysfunction (blood pressure240 umol/L,Cr>500 µmol/L), lipid metabolism disorder (triacylglycerol > 4~5mmol/L, acidosis (serum lactic acid > 3~4mmol/L, pH < 7.2); (2) Patients with gastrointestinal diseases, such as ischemic bowel disease, intestinal perforation, acute gastrointestinal massive hemorrhage and intestinal obstruction; (3) Patient's Modified Rankin Scale (MRS) score before admission is = 3 points; (4) Chronic disease life expectancy<6 months; (5) Those who received albumin infusion before enrollment; (6) Patients with whey protein allergy; (7) Pregnant and lactating women.

Design outcomes

Primary

Measure	Time frame
Total protein;albumin;Prealbumin;Hemoglobin;	—

Secondary

Measure	Time frame
Leukocyte;Procalcitonin;	—

Countries

China

Contacts

Public ContactZhang Xia

Affiliated Hospital of Zunyi Medical University, Dalian Road, Huichuan District, Zunyi City,

396062066@qq.com+86 150 8609 7963

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026