Sleep regulation and neural network oscillation of rhythmic visual stimulation in patients with prolonged disorders of consciousness

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300079317

Enrollment

Unknown

Registered

2023-12-30

Start date

2024-01-01

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

disorders of consciousness

Interventions

experimental group:rhythmic visual stimulation

control group:non-rhythmic visual stimulation

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Conformed to MCS international diagnostic criteria formulated by Giacino in 2002 or UWS diagnostic criteria proposed by Laureys in 2010; 2. The course of disease is more than 28 days; no improvement tendency in the past 1 month; 3. No sedative or antiepileptic drugs were used in the past 1 month; 4. Stable vital signs ; 5. No obvious hydrocephalus, cerebral edema or severe cerebral atrophy; 6. Age from 18 to 70 years old; 7.Family members sign informed consent form.

Exclusion criteria

Exclusion criteria: 1. Previous history of neurological or psychiatric disorders; 2. Previous history of traumatic brain injury; 3. Have a history of tumor; 4. Have taken sedative drugs or antiepileptic drugs in the past 1 month; 5. Unstable vital signs; 6. Obvious skull defect; 7.Family members refused to sign informed consent form.

Design outcomes

Primary

Measure	Time frame
CRS-R;SECONEs;	—

Secondary

Measure	Time frame
GOS-E;EEG;fNIRS;DRS;	—

Countries

China

Contacts

Public ContactLi Zhang

Zhejiang Provincial People's Hospital

zhangli0407@zju.edu.cn+86 137 3227 4598

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026