Preoperative sleep and cognitive impairment
Conditions
Interventions
Low level BIS group:Maintain intraoperative BIS values between 40-60 through BIS monitoring
High level BIS group:Maintain intraoperative BIS values between 60-80 through BIS monitoring
Non BIS monitoring group:None
Sponsors
Department of Anesthesiology,Chifeng Municipal Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged over 65 years; 2. Preoperative patients who plan to undergo elective hip or knee arthroplasty; 3. Patients receiving intraspinal anesthesia; 4. Voluntarily participate in the clinical trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those with a history of craniocerebral trauma or multiple trauma; 2. Drug-dependent patients; 3. Patients with mental and mental illness; 4. Patients with dementia or cognitive dysfunction; 5. Those who cannot understand the test-related scoring scales and who do not cooperate with the evaluation; 6. Patients with missing cerebrospinal fluid and blood samples; 7. Patients with preoperative anesthetic drugs; 8. Preoperative patients undergoing emergency orthopedic surgery; 9. Participated in other clinical trials within 3 months before inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| preoperative sleep quality;postoperative cognitive impairment;Aß42;p-tau;S100ß;NSE; | — |
Countries
China
Contacts
Public ContactZhou Qi
Chifeng Municipal Hospital
Outcome results
None listed