valvular heart disease
Conditions
Interventions
GDF-15 elevated group:Samples were collected and GDF-15 levels were detected at before the start of surgery, before cardiopulmonary bypass, 5 minutes after the removal of aortic cross-clamp, the 30 mi
GDF-15 did not increase group:Samples were collected and GDF-15 levels were detected at before the start of surgery, before cardiopulmonary bypass, 5 minutes after the removal of aortic cross-clamp, t
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patient age > 18 years old; (2)ASA grade II-?; (3) Rheumatic and degenerative valve disease patients who need to undergo valve replacement at an appropriate time are all replaced for the first time.
Exclusion criteria
Exclusion criteria: ?Patients with other significant coronary artery disease (=50% stenosis) or other significant cardiac abnormalities; ? Patients who underwent coronary artery bypass grafting at the same time; ? Because of serious liver disease or blood system disease, including hemophilia, affecting the patient's blood clotting function; ? Patients with severe renal insufficiency (endogenous creatinine clearance ?20mL/min); ?Due to tumor diseases (such as hematopoietic system dysfunction, etc.), obvious bleeding tendency; ?6 months before surgery, cerebrovascular accident, including transient ischemic attack; ? Incomplete medical history, laboratory and imaging data.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Postoperative blood transfusion;overlengthy case in hospital stays;Incidence of postoperative complications;Reoperation situation;Early mortality; | — |
Primary
| Measure | Time frame |
|---|---|
| Drainage volume within the first 24 hours after operation; | — |
Countries
China
Contacts
Public ContactJun Ma
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed