cardiac surgery
Conditions
Interventions
Group A:Cytokine adsorption techniques were used during intraoperative and postoperative dexmedetomidine pumping combined with extracorporeal circulation.
Group B:Intraoperative and postoperative dexmedetomidine pumping combined with standard extracorporeal circulation.
Group C:Cytokine adsorption techniques were used during intraoperative and postoperative pumping of 0.9% Saline combined with extracorporeal circulation.
Group D:Intraoperative and postoperative pumping of 0.9% Saline combined with standard extracorporeal circulation.
Sponsors
The First Affiliated hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Adult patients (age =18 years) who were scheduled to undergo extracorporeal cardiac surgery under general anaesthesia, including coronary artery bypass grafting, valve surgery, or combined coronary artery bypass graft valve replacement, were included in this study.
Exclusion criteria
Exclusion criteria: Patients meeting any of the following criteria would be excluded: (1) refusal to provide written informed consent; (2) preoperative history of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or severe dementia; (3) inability to communicate due to visual, hearing, speech, or other impairments; (4) history of brain injury or neurosurgery; (5) left ventricular ejection fraction <30%; (6) history of morbid sinus node syndrome, history of severe bradycardia (heart rate <50 beats per minute), or =2 degrees of atrioventricular block; (7) severe hepatic failure (Child-Pugh class C); (8) severe renal failure (requiring renal replacement therapy); and (9) patients with allergies to experimental medications and to haemoperfusion devices, filters, and anticoagulants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of perioperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative changes in cognitive function;Inflammatory factor levels;Brain injury marker levels; | — |
Countries
China
Contacts
Public ContactCheng Hu
The First Affiliated hospital of Xinjiang Medical University
Outcome results
None listed