neurocritical disease
Conditions
Interventions
Case series:NA
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Neurocritical patients admitted to the Neurosurgical Intensive Care Unit : those with acute consciousness disorders (GCS score = 8 points); or severe neurological dysfunction (NIHSS score = 17 points); or evident primary intracranial injuries, characterized by bleeding volume = 30 mL, or midline structural displacement > 5 mm. 2) Age 18-85 years old. 3) Patients or their family members sign an informed consent form. 4) Patients with clinically supported increased intracranial pressure (evidenced by coma, vomiting, and radiological features of intracranial hypertension) may undergo intraventricular intracranial pressure monitoring. This criterion is exempt for patients undergoing solely neuroendocrine function assessment or those suspected of intracranial infection. 5) Patients with clinically supported intracranial infection (evidenced by fever and abnormal cerebrospinal fluid indicators) agree to undergo macro-genomic sequencing of cerebrospinal fluid. This criterion is exempt for patients undergoing solely intracranial pressure/cerebral hemodynamic assessment or neuroendocrine function assessment.
Exclusion criteria
Exclusion criteria: 1) Individuals with severe liver or kidney dysfunction, severe endocrine disorders, heart failure, or severe immunodeficiency. 2) Those with concurrent significant injuries to other vital organs. 3) Anticipated life expectancy less than 1 month. 4) Refusal to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure;Cerebral blood perfusion;perihematomal edema volume;mRS;rate of CNS infection; | — |
Secondary
| Measure | Time frame |
|---|---|
| length of intensive care;length of Mechanical ventilation;medical cost; | — |
Countries
China
Contacts
Public ContactJunji Wei
Peking Union Medical College Hospital
Outcome results
None listed