PCOS
Conditions
Interventions
Al group:Orally take Kuntai capsule, 4 pills / time, 3 times / day, for three months, non-stop during menstrual time.
A2 group:Orally take Kuntai capsule, 4 pills / time, 3 times / day, for three months, non-stop during menstrual time.
B group:no
Sponsors
Hangzhou Obstetrics and Gynecology Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1Patients meet the diagnostic criteria of the 2003 European Society for Human Reproductive and Embryology in Rotterdam and the American Society of Reproductive Medicine (ESHRE / ASRM), which requires any 2 of the following 3 items: 1) rare ovulation and / or anovulation; 2) clinical manifestations and / or excessive androgens; or 3) ultrasound detection of ovarian polycystic changes: with =12 follicles of 2-9mm in diameter in one /both ovaries,ovarian volume= 10 ml in one /both ovaries;2. Patients are evaluated by the steady-state model insulin resistance index (homeostasis model assessment-insulin resistance index, HOMA-IR), HOMA-IR= 2.69 is regarded as IR, otherwise not IR;3. Women aged between the ages of 18 and 40 years;4. 18=BMI=35 kg/m2;5.Patients have no family planning in recent 3 months;6. Patients are ability to follow the protocol for treatment, examination, and follow-up;7.Patients are consent, voluntary to be tested.
Exclusion criteria
Exclusion criteria: 1. Patients are pregnant or suspected pregnancy;2. Patients have taken drugs that may affect the function or metabolism of the reproductive axis, including oral contraceptives, estrogen, GnRH, antiandrogen drugs, weight-loss drugs, antibiotics and related drugs affecting intestinal flora, such as probiotics,in the past one month;3.Patients with other endocrine disorders, such as diabetes mellitus, congenital adrenal hyperplasia, 21 hydroxylase deficiency, hyperprolactinemia, androgen-secreting tumor, uncorrected thyroid disease, or suspected Cushing syndrome;4.Patients with severe medical diseases, such as liver and renal insufficiency, cardiac insufficiency, severe infection and trauma, hypotension, etc;5.Patients with major surgical histories;6.Patients with hemolytic anemia and G6PD deficiency;7.Patients with mental disorders;8.Patients with allergy to Kuntai capsule;9. Patients who are addicted to tobacco and alcohol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| flora analysis in stool samples;blood fat ; | — |
Secondary
| Measure | Time frame |
|---|---|
| sex hormone;Serum glucose;Fasting serum insulin;OGTT;BMI;WHR ;Menstruation scores;acne scores;hirsutism scores; | — |
Countries
China
Contacts
Public ContactZhou Jie
Hangzhou Obstetrics and Gynecology Hospital
Outcome results
None listed