Acute ischemic stroke
Conditions
Interventions
Endovascular thrombectomy group:Endovascular thrombectomy
Non endovascular thrombectomy group:Conventional drug treatment
Sponsors
The First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 18-80 years old; meeting the diagnostic criteria for acute ischemic stroke (AIS), onset =24 hours, NIHSS = 8, and confirmation of responsible vessel occlusion in the middle cerebral artery M1 segment or internal carotid artery by MRA or CTA; first-ever AIS or previous history of AIS with pre-stroke mRS score = 1; meeting the indications for endovascular therapy as outlined in the "Chinese Guidelines for Early Endovascular Intervention in Acute Ischemic Stroke 2022"; consent form signed by the patient or legal representative.
Exclusion criteria
Exclusion criteria: Secondary intracerebral hemorrhage; critically ill, with estimated survival of less than 3 months; history of previous organic brain diseases such as traumatic brain injury, central nervous system infections, brain tumors, etc.; history of dementia or cognitive decline prior to AIS; diseases associated with Aß pathology: cerebral amyloid angiopathy, Parkinson's disease, Huntington's disease; inability to cooperate with cognitive function assessments, such as severe language or mental disorders; allergy to 11C-PIB imaging agent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ß-amyloid in the brain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-mental State Examination;Montreal Cognitive Assessment ;Plasma ß-amyloid; | — |
Countries
China
Contacts
Public ContactYusheng Zhang
The First Affiliated Hospital of Jinan University
Outcome results
None listed