Coronary Heart Disease and Periodontal Disease
Conditions
Interventions
Mild periodontal disease group/Moderate periodontal disease group/Severe periodontal disease group:None
Sponsors
the First Affiliated Hospital of Henan University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients hospitalized in the Department of Cardiology of the First Affiliated Hospital of Henan University of Science and Technology from January 2024 to June 2024 were enrolled. 2. Coronary angiography was performed to confirm the diagnosis of coronary heart disease. 3. Patients who consented to undergo carotid ultrasonography and dental examination. 4.Informed consent was obtained.
Exclusion criteria
Exclusion criteria: 1. Patients aged 65 years. 2. Patients with a previously established diagnosis of coronary artery disease. 3. Patients who had previously been diagnosed with periodontal disease and received dental intervention. 4. Patients with severe valvular disease and heart failure (NYHA class ?~?). 5. Severe renal failure (glomerular filtration rate 220mmol/L (2.5mg/dl)), or hemodialysis treatment. 6. Inability to communicate due to severe cognitive impairment or other reasons. 7. Acute myocardial infarction. 8. The expected survival time is less than 1 year (combined with malignant tumor, severe heart and lung diseases, etc.). 9. Participated in other interventional clinical studies that may have affected the assessment of outcomes. 10. Severe liver dysfunction. 11. Other conditions considered by the investigator to be inappropriate for participation in the study or likely to pose a significant risk to the patient (e.g., inability to understand and/or comply with study procedures and/or follow-up due to mental illness, cognitive or emotional disorder). 12. Patients currently taking immunosuppressive agents or undergoing immunotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Major adverse cardiovascular events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Periodontal disease severity;Quantification of porphyromonas gingivalis;Carotid intimedia thickness;Laboratory indexes; | — |
Countries
China
Contacts
Public ContactYingle Wu
the First Affiliated Hospital of Henan University of Science and Technology
Outcome results
None listed