laparoscopic or abdominal gynecological surgery
Conditions
Interventions
Propofol group (Group P):Propofol 2–3 mg/kg. At the beginning of anesthesia induction, both groups received continuous pump infusion of remifentanil 0.15ug/(kg·min), dexmedetomidine 0.5ug/kg·h, and in
Remimazolam group (group R):Remimazolam 0.2–0.3 mg/k. At the beginning of anesthesia induction, both groups received continuous pump infusion of remifentanil 0.15ug/(kg·min),
exmedetomidine 0.5ug/kg·
Sponsors
The Second Hospital of Dalian Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 59 Years
Inclusion criteria
Inclusion criteria: ?Patients undergoing elective laparoscopic or abdominal gynecological surgery induced by intravenous general anesthesia with remimazolam or propofol; ?Age 20-59 years old; ?American Society of Anesthesiology(ASA) 1-2; ?18<BMI<30.
Exclusion criteria
Exclusion criteria: ?American Society of Anesthesiology(ASA) 3 and above; ?hyperthyroidism; ?hypothyroidism; ?hypovolemia; ?severe liver and kidney disease; ?left ventricular EF <55%; ?cardiomyopathy; ?severe coronary artery disease; ?valvular disease; ?severe arrhythmia ; ? Previous cardiac surgery history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters during anesthesia induction(heart rate, blood pressure);Echocardiography traditional cardiac function parameters (LVEF, FAC, S’, TAPSE);Myocardial strain ,myocardial work and ventricular-arterial coupling parameters(LVGLS,RVGLS,RVFWLS,GWI,GCW,GWE,GWW); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse events during anesthesia induction; | — |
Countries
China
Contacts
Public ContactWu Jun
The Second Hospital of Dalian Medical University
Outcome results
None listed