Angioimmunoblastic T cell lymphoma
Conditions
Interventions
Therapy group: Azacitidine and Chidamide in combination with Mitoxantrone Hydrochloride Liposome
Sponsors
The First Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. AITL patients were confirmed by pathology. 2.Age 18-70, male or female. 3. ECOG score is 0-2. 4. Obtain informed consent signed by the patient or family member.
Exclusion criteria
Exclusion criteria: 1. Received systemic or local treatment including chemotherapy in the first three weeks. 2. Liver and kidney function: blood bilirubin > 2 mg/dl (35 umol/L), AST/ALT was more than 2 times of the upper limit of normal, serum creatinine was more than 177 umol/L, the creatinine clearance rate was less than 60 ml/min. 3. Normal heart function: EF <= 50%. 4. The expected survival time was less than 3 months. 5. Chronic or current active infectious diseases requiring systemic antibiotics, antifungal agents or antiviral therapy. 6. Other concurrent and uncontrollable factors are considered by the researchers to affect the medical status of patients participating in the study. Psychiatric patients or other patients who are known or suspected to be unable to fully comply with the study protocol. 7. People living with HIV.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression free survival;Overall survival;Objective response rate;Safety; | — |
Countries
China
Contacts
Public ContactHongyan Tong
The First Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed