Different concentrations of glycerol enema for meconium evacuation in preterm infants

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300079199

Enrollment

Unknown

Registered

2023-12-27

Start date

2024-01-01

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

feeding intolerance

Interventions

group 1:Saline (mL): glycerol enema (mL)= 9:1

group 2:Saline (mL): glycerol enema (mL)= 7:3

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ? birth weight 1000~1499g; ? admission to the NICU within 24h after birth.

Exclusion criteria

Exclusion criteria: ? Gastrointestinal malformations (tracheoesophageal fistula, megacolon, intestinal atresia and stenosis, anal and rectal malformations, diaphragmatic hernia, etc.); ? Asphyxia (1-minute or 5-minute Apgar score = 7); ? Severe infections; ?Suspected or diagnosed inherited chromosomal or metabolic disorders; ?Suffering from complex congenital heart disease.

Design outcomes

Primary

Measure	Time frame
rectal bleeding;NEC;	—

Secondary

Measure	Time frame
feeding intolerance;Stool weight after enema;time to reach full enteral feeding;time to reach transitional stool;time to evacuate fetal stools;duration of parenteral nutrition;rate of milk increase before reaching full enteral nutrition;regional intestinal oxygen saturation;	—

Countries

China

Contacts

Public ContactXia LI

West China Second University Hospital, Sichuan University

lixiakoko94@163.com+86 173 6026 8415

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026