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The Effect of Ulinastatin on Early Resuscitation in Patients with Hypovolemic Shock:A Prospective, Multicenter, Cohort Study

The Effect of Ulinastatin on Early Resuscitation in Patients with Hypovolemic Shock:A Prospective, Multicenter, Cohort Study

Status
Recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300079180
Enrollment
Unknown
Registered
2023-12-27
Start date
2024-01-01
Completion date
Unknown
Last updated
2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypovolemic shock

Interventions

Blank countercolumn group:NA

Sponsors

Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1)Sign informed consent voluntarily (2)Age = 18 years old (3)Hypovolemic shock was diagnosed (meeting one of the following 1+2/3+4/5/6/7) : 1. The patient has a high risk factor or disease (such as trauma, gastrointestinal bleeding, or heat attack) that causes blood volume loss, including fluid loss and blood loss 2. Decreased blood pressure, systolic blood pressure 2s) 6. Spotted skin, pale mucosa or cyanosis, urine volume 100 beats/min or can not be touched, shock index > 1.0.

Exclusion criteria

Exclusion criteria: (1)Have an autoimmune disease (such as cancer, HIV) (2)Patients who received excessive doses of hormone (prednisone 30-100 mg/ d or equivalent dose) and immunosuppressants within 1 month (3)Patients with serious underlying diseases, such as chronic kidney failure and liver failure

Design outcomes

Primary

MeasureTime frame
Blood product dosage;Vasoactive drug dosage;the time of mean arterial pressure = 65mmHg;difference and dynamic change of arterial lactate, base residual, hematocrit and hemoglobin levels;The time of urine volume, nerve function (disturbance of consciousness) return to normal;The time of mean arterial pressure =65mmHg in 72h;

Countries

China

Contacts

Public ContactJiang Longyuan

Sun Yat-sen Memorial Hospital, Sun Yat-sen University

jly1964@vip.163.com+86 133 1280 9001

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026