Cerebrovascular disease
Conditions
Interventions
Remote ischemic conditioning treatment group:RIC treatment was initiated within 24 hours of the subjects enrollment (The RIC protocol included 5 cycles of bilateral upper arms with 5-minute inflation
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University.
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1: Age >=18 years old. 2: Atherosclerotic non-acute internal carotid artery occlusion diagnosed by imaging (MRA/CTA) and confirmed by DSA. 3: Hypoperfusion cerebral infarction caused by diseased vessels and the onset time was more than 24 hours. 4: Meet the indications of intravascular interventional therapy. 5: Informed consent was obtained from the patient or his legal representative.
Exclusion criteria
Exclusion criteria: 1: Symptom worsened within 48 hours of admission (NIHSS score increase >= 4 points). 2: Modified Rankin Scale score>2 points before the onset of this disease. 3: Combined intracranial hemorrhage. 4: Expected RIC treatment cycle<7 days. 5: Inability to tolerate or refuse intravascular intervention therapy. 6: Inability to receive antiplatelet therapy for any reason. 7: History of moyamoya disease, vasculitis, dissection, etc. 8: High risk factors for concomitant cardiac embolism (such as atrial fibrillation, mitral stenosis, artificial valves, bacterial endocarditis, etc.). 9: Expected survival time<1 year or inability to complete follow-up. 10: Pregnancy, lactation, or severe complications (end-stage renal disease, liver failure, severe COPD, acute myocardial infarction, etc.). 11: Subjects with severe upper limb soft tissue injury, fractures or thrombosis, other known peripheral vascular lesions, active visceral bleeding, acute phase of fundus hemorrhage, cerebral aneurysms or cerebral arteriovenous malformations, and other subjects deemed unsuitable for RIC treatment by researchers. 12: Other conditions that researchers determines may affect the efficacy or safety evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of positive prognosis (mRS = 2).; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of cerebral hyperperfusion syndrome.;Postoperative vascular recanalization rate.;Incidence of intracranial hemorrhage.;Recurrence rate of cerebral infarction in the area of responsible artery supply.;Postoperative vascular restenosis rate;All-cause mortality rate.;Stroke-related mortality.;Cognitive function;Proportion of positive prognosis (mRS = 2).;Recurrence rate of symptomatic cerebral infarction.;The incidence of symptomatic intracranial hemorrhage.; | — |
Countries
China
Contacts
Public ContactFude Liu
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed